James Bolling

James Bolling

Company: Precision BioSciences

Job title: Senior Director, Cell Therapy Process Development


Case Study: Finding the Right Scale for Allogeneic CAR-T Cells and Simplifying Processes to Balance Time and Quality at Scale 9:00 am

• Contrasting product quality and cell fitness at small vs. large scale, and strategies to create simpler, scalable processes with minimal compromise to fitness • Balancing scale of expansion and achieving target product profiles to ‘find the right scale’ for product batches • Experimenting with cryopreservation protocols to examine freezing profiles and optimize processes for…Read more

day: Day Two

Panel Discussion: Reflecting on the Trials, Tribulations, Victories and Remaining Hurdles in Process Development Across Contrasting Allogeneic Sources 3:00 pm

• Contrasting the process development steps, and relative advantages and pitfalls between different allogeneic sources from iPSC-derived, healthy donor, and umbilical cord-derived cells • Highlighting synergies and learnings that can be applied from the autologous field, and areas where innovation and a ‘clean slate’ is required to optimize platforms • Sharing experience of process development…Read more

day: Day One

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