Shyam Subramanian

Shyam Subramanian

Company: Obsidian Therapeutics

Job title: CTO


Driving Manufacturing Process Innovation for Engineering and Expansion of Tumor-Infiltrating Lymphocytes 10:00 am

• Discussing the current state of TIL manufacturing processes and need for innovation • Optimizing viral vector engineering of TILs for transgene expression • Implementing novel feeders to support robust expansion of engineered TILs • Innovating continuously for reduced COGS, close processing and automationRead more

day: Day Two

Discussing How Product Characteristics Can Streamline Process to Improve Process Simplicity and Reduce COGS 12:30 pm

• Characterizing tumor infiltrating lymphocyte product expressing membrane bound IL15 and impact of process on product quality • Improving process design to leverage product characteristics and optimizing cytokine supplementation • Discussing challenges and lessons learned in this process development, and benefits from cytokine regimen optimization  Read more

day: Day One

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