Advancing Cryopreservation for Cell Therapy: From Cryoformulations, Controlled-Rate Freezing to Clinical Readiness
- Evaluate an integrated framework for optimizing cryopreservation of cell therapy products, combining advanced cryoformulation characterization with engineered controlled‑rate freezing processes for efficient freezing and scale up
- Understand how reduced‑DMSO and DMSO‑free formulations, along with precise ice‑nucleation and cooling‑rate strategies, improve post‑thaw viability, apoptosis profiles, and cellular fitness
- Review critical temperature‑handling limits based on intracellular glass‑transition behavior, ensuring safe storage and transport and robust clinical manufacturing of CAR‑T drug products