Jimmy Chan
Research Fellow Olivia Newton-John Cancer Research Institute
Jimmy Chan, Research Fellow, Olivia Newton-John Cancer Research Institute, specializes in unconventional gamma delta T cell immunotherapy development. His research focuses on isolating and expanding rare gamma delta T cell subsets (V delta 1, 2, and 3) from healthy donors and cancer patients including triple-negative breast cancer and melanoma. Using proprietary expansion methods, Kok Fei’s team scales cells from thousands to over 100 billion while maintaining therapeutic phenotype and achieving over 90% tumor cell killing in vitro. His work addresses critical challenges in process characterization, automation strategies for scaling, and understanding tumor microenvironment interactions to advance allogeneic cell therapy development.
Seminars
- Implementing proprietary expansion methods to scale unconventional gamma delta T cells from low starting numbers to over 100 billion cells while maintaining therapeutic phenotype and functional markers
- Establishing quality control processes using flow cytometry to characterize cells before and after expansion, ensuring potential activation and anti-tumor cytotoxicity exceeding 90 percent
- Investigating tumor microenvironment interactions and immune evasion mechanisms to optimize gamma delta T cell product quality and overcome exhaustion for consistent therapeutic efficacy
