Nirnoy Dan
Senior Scientist AstraZeneca
Nirnoy Dan is a Senior Scientist at AstraZeneca, where he focuses on downstream process development for CAR-T cell therapies, including both autologous and allogeneic platforms. His work centers on critical formulation, fill-finish, and cryopreservation processes that translate cell therapies from discovery to clinical manufacturing. Nirnoy earned his Ph.D. in Pharmaceutical Sciences from the University of Connecticut and holds an M.S. from the University of Tennessee Health Science Center. He is a published researcher in drug delivery and antibody-drug conjugates.
Seminars
Thursday 16th July 2026
Advancing Cryopreservation for Cell Therapy: From Cryoformulations, Controlled-Rate Freezing to Clinical Readiness
11:45 am
- Evaluate an integrated framework for optimizing cryopreservation of cell therapy products, combining advanced cryoformulation characterization with engineered controlled‑rate freezing processes for efficient freezing and scale up
- Understand how reduced‑DMSO and DMSO‑free formulations, along with precise ice‑nucleation and cooling‑rate strategies, improve post‑thaw viability, apoptosis profiles, and cellular fitness
- Review critical temperature‑handling limits based on intracellular glass‑transition behavior, ensuring safe storage and transport and robust clinical manufacturing of CAR‑T drug products
