Sagar Sharma
Scientist Cabaletta Bio
Sagar is a Process Development scientist at Cabaletta Bio, a clinical-stage biotechnology company pioneering engineered T cell therapies for autoimmune diseases. He has over five years of cross-functional CMC experience in cell therapy developing next generation manufacturing platforms for tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cells and supporting continuous process improvement. Sagar is passionate about creating processes that can reliably and consistently supply patients with quality drug products and holds a B.S. from the University of Pittsburgh.
Seminars
Starting material limitations and quality issues pose significant risks to cell therapy
process development, yet is often identified too late. Donor-to-donor variability,
cryopreservation losses, and inadequate material for analytical validation create
bottlenecks across functions. Join this workshop to discuss strategies for classifying
donors, optimizing cell recovery post-thaw, addressing media composition challenges,
and ensuring cross-functional teams have sufficient high-quality material for both
process development and analytical testing.
This workshop will gather experts to discuss:
- Optimizing cryopreservation and thawing protocols to minimize cell loss and maintain viability for consistent downstream processing
- Classifying donors and implementing manufacturing adaptations based on variability to control process parameters and ensure product quality
- Addressing cell culture media composition uncertainties and logistical challenges to improve starting material consistency across disease indications
- Coordinating between process development and analytical teams to secure sufficient quality material for validation, qualification, and robust testing
